Catecholamines and Recovery of Function after Brain Damage

摘要: Amphetamine (AMP) induces a temporary restoration of tactile placing responses in cats with unilateral sensorimotor cortex injury and an enduring acceleration recovery the hemiplegic rat cat. Improved locomotor ability occurs within hours after single dose drug, but only if experience is provided during period drug action. Following bilateral visual ablation cats, binocular depth perception restored by four doses AMP given intoxication. These beneficial effects are blocked haloperidol, which also retards when alone, implicating catecholamines recovery. The effect on has been extended to models stroke cortical contusion. Although analogues cat hemiplegia models, drugs affecting primarily dopamine system were not effective. Additional studies have implicated norepinephrine (NE) effect. maintenance may depend NE, since some α-noradrenergic antagonists reinstate symptoms recovered animals. injuries produce widespread metabolic depression, improved worsened haloperidol. plus relevant treatment most compatible theory diaschisis or concept “remote functional depression” brain that reversible intervention. Preliminary data indicate similar produced humans injury, catecholamine retard from aphasia, combined physical therapy improves motor performance patients.