Amphetamines for improving recovery after stroke.

摘要: Background Animal research shows that treatment with amphetamines improves recovery after focal cerebral ischaemia. If the effects are similar in humans, amphetamine could have a major impact on from stroke. Objectives To assess of patients stroke. Search methods We searched Cochrane Stroke Group Trials Register (last January 2006), Central Controlled (The Library Issue 1, MEDLINE (1966 to EMBASE (1980 CINAHL (1982 Science Citation Index (1992 March 2005) and registers ongoing trials. We also checked reference lists all relevant articles reviews, contacted researchers field. Selection criteria Randomized unconfounded trials comparing placebo. Data collection analysis Two review authors independently selected for inclusion assessed trial quality; one extracted data. Main results Ten studies involving 287 were included, but not contributed data each outcome examined this review. The quality varied was generally high. Based three (106 patients) there no evidence reduced death or dependence (Peto's odds ratio (Peto OR) 1.5, 95% confidence interval (CI) 0.6 3.3). Imbalances at baseline more serious stroke allocated may account trend deaths end follow up among amphetamine-allocated OR 2.8, CI 0.9 8.6). two (73 systolic (weighted mean difference (WMD) 8.4 mm Hg, 1.6 15.2) diastolic (WMD 4.9 1.1 8.8) blood pressure, as well heart rate, increased 10.6 bpm, 3.3 17.8) patients. six (176 better relative change last motor function -6.1 points; -10.4 -1.9) Different results different analysis approaches emphasize caution interpretation results. Authors' conclusions At present, too few been studied draw any definite conclusions about stroke. suggested benefits non-significant towards risk be related imbalances prognostic variables other bias studies. Further is therefore justified.