A protein knockdown strategy to study the function of β-catenin in tumorigenesis
作者： Feng Cong , Jianxuan Zhang , William Pao , Pengbo Zhou , Harold Varmus
关键词: Adenomatous polyposis coli 、 LRP5 、 Biology 、 LRP6 、 Catenin 、 Cell biology 、 Beta-catenin 、 Wnt signaling pathway 、 Cell fate determination 、 Signal transduction
摘要: Background The Wnt signaling pathway plays critical roles in cell proliferation and fate determination at many stages of development. A downstream target is the cytosolic β-catenin, which stabilized upon activation promotes transcription a variety genes including c-myc cyclin D. Aberrant signaling, results from mutations either β-catenin or adenomatous polyposis coli (APC), renders resistant to degradation, has been associated with multiple types human cancers.
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