Cell-cell adhesion in invasion and metastasis of carcinomas.

摘要: Metastasis of tumor cells involves a series consecutive attachment and deattachment events that are based on multitude specific cell-to-cell cell-to-substrate interactions. The process is initiated by disaggregation invasive from the primary carcinoma — step requires breakdown intercellular adhesion (see below for detailed discussion). Invasion then depends novel adhesive interactions with extracellular matrix components basement membrane mesenchymal tissue. hallmark invasion (in particular in carcinomas) penetration through surrounding indicates transition benign situ to malignant tumor. This digestion molecules, like laminin collagen type IV. It has been shown, instance, express elevated levels IV collagenase both receptors [1,2]. A similar combination changes proteolytic activities also aids their movement interstitial stroma membranes blood vessels. For metastasis formation vivo could be suppressed injection cell peptide YIGSR located Bl chain [3]. Various experiments have shown proteins containing RGD amino acid sequence recognition integrin serve as substrates migrating [4, 5, 6]. An important role was revealed expression α2 cDNA low metastatic rhabdomyosarcoma cells. transfected expressed functional α2β1 receptors, they exhibited enhanced vitro, produced more colonies nude mice comparison parental [7]. Interestingly, transformation rodent oncogenic viruses resulted decrease [8], overexpression a5βl transformed Chinese hamster ovary reduced tumorigenicity motility [9]. These results reveal dual tumorigenesis: one hand, required locomotion, but other it can impose constraints growth thus must minimized certain cases [10].