Association of HDAC8 Expression with Pathological Findings in Triple Negative and Non-Triple Negative Breast Cancer: Implications for Diagnosis.

摘要: Background Previous data have shown the tumorigenicity roles of histone deacetylase 8 (HDAC 8) in breast cancer. More recently, oncogenic effects this molecule been revealed triple negative cancer (TNBC). The present study aimed to determine diagnostic value HDAC8 for differentiation TNBC from nTNBC tumors. Methods A total 50 cancerous and normal adjacent tumor specimens were obtained, clinical pathological findings studied subjects recorded. expression gene was determined by qRT-PCR. Also, immunohistochemical staining performed on tissue samples. Results Our results showed that tissues significantly higher than (p = 0.0011). also observed be patients group 0.0013). In addition, group, there a significant association between overexpression characteristics, including size 0.039), lymphatic invasion 0.01), grade 0.02), perineural < 0.05). cut-off fixed at 0.6279 r.u., corresponding sensitivity specificity found 73.91% 70.37%, respectively. Conclusion According findings, among other markers, oncogene may used as potential marker diagnosis