Treating degenerative dementia using low intensity focused ultrasound pulsation (lifup) device
作者： Alex Korb , Shelly Jordan , Mark Evan Schafer , Walter William Wurster
DOI:
关键词: Astrocyte 、 Brain tissue 、 Hippocampus 、 Neuroscience 、 Degenerative dementia 、 Medicine 、 Focused ultrasound 、 Ultrasonic sensor 、 Slow-wave sleep 、 Intensity (physics)
摘要: Ultrasonic energy is used for treating degenerative dementia. A focal point of an ultrasonic transducer beam directed at a target area the brain to promote removal substances that accumulate in interstitial pathways are least partially responsible In one example, may comprise hippocampus and dementia be Alzheimer's disease. The stimulate tissue frequency corresponds naturally occurring deep sleep burst neurons subsequent astrocyte activation patterns drive convective process solute disposal. For generate between 1-4 hertz functions help remove amyloid plaque.
lens.org 参考文章(10)
Meaghan O'reilly, Kullervo Hynynen, Multi-frequency ultrasound device and method of operation ,(2013)
Carol Tosaya, John Sliwa, Acoustically-aided cerebrospinal-fluid manipulation for neurodegenerative disease therapy ,(2004)
Michael Allen Gustafson, Walter William Wurster, Richard Alan Waltz, Elaine Patrice Pelletier, Focused ultrasonic transducer navigation system ,(2012)
Alexander Bystritsky, Alex S. Korb, Pamela K. Douglas, Mark S. Cohen, William P. Melega, Amit P. Mulgaonkar, Antonio DeSalles, Byoung-Kyong Min, Seung-Schik Yoo, A review of low-intensity focused ultrasound pulsation. Brain Stimulation. ,vol. 4, pp. 125- 136 ,(2011) , 10.1016/J.BRS.2011.03.007
Jessica F. Jordão, Emmanuel Thévenot, Kelly Markham-Coultes, Tiffany Scarcelli, Ying-Qi Weng, Kristiana Xhima, Meaghan O'Reilly, Yuexi Huang, JoAnne McLaurin, Kullervo Hynynen, Isabelle Aubert, Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound Experimental Neurology. ,vol. 248, pp. 16- 29 ,(2013) , 10.1016/J.EXPNEUROL.2013.05.008
Gerhard Leinenga, Jürgen Götz, Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model Science Translational Medicine. ,vol. 7, ,(2015) , 10.1126/SCITRANSLMED.AAA2512
Jan Bieschke, Martin Pitschke, Karin Post, Oliver Schaefer, Manfred Eigen, Detlev Riesner, Method for measuring the association of substructures of pathological protein deposits ,(1998)
Sato Hiroki, Funane Tsukasa, Energy emission device ,(2017)