Matrix Metalloproteinases
作者： Laurie A. Shuman Moss , Sandra Jensen-Taubman , William G. Stetler-Stevenson
DOI: 10.1016/J.AJPATH.2012.08.044
关键词: Disease 、 Angiogenesis 、 Matrix metalloproteinase 、 Tumor microenvironment 、 Cancer research 、 Extracellular matrix 、 Medicine 、 Inflammation 、 Tumor progression 、 Pathology 、 Metastasis
摘要: Articles on tumor invasion, metastasis, and angiogenesis in normal disease states have been well represented among the pages of The American Journal Pathology. In addition to exciting interest a variety processes, these studies central defining emerging field cancer research known as microenvironment. Early this established importance extracellular matrix cell growth differentiation. With time, role metalloproteinases regulation was recognized, AJP has published seminal articles field. Moreover, recent show evidence for inflammation within lesions, making targeting therapy even more complex. This review attempts summarize contribution some key changes that led evolution
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