Effect of Taurine on Prostate-Specific Antigen Level and Migration in Human Prostate Cancer Cells

摘要: In Korea, prostate cancer incidence has significantly increased in recent years. Prostate-specific antigen (PSA) is a marker for cancer, and elevated serum PSA levels have been associated with intraepithelial neoplasms. Meanwhile, metastasis process by which spreads from the place at it first arose as primary tumor to distant locations body. The so-called tissue inhibitors of metalloproteinases (TIMPs), are naturally occurring matrix (MMPs), play an important role complex regulation MMPs. They inhibit catalytic activity MMPs binding activated control breakdown extracellular matrix. Thus, balance between TIMPs plays vital maintaining integrity healthy tissues, MMP inhibitors, well TIMP activators, expected be useful chemotherapeutic agents treatment malignancies. addition, vascular endothelial growth factor (VEGF) invasion. VEGF signal protein produced cells that stimulates vasculogenesis angiogenesis. present study, therefore, we investigated anti-prostate effect taurine, proved taurine suppressed several metastasis-related genes human cells, LNCaP PC-3. inhibited migration