Estimating the power of a proposed linkage study: a practical computer simulation approach.

摘要: I describe a simulation method to estimate the power detect linkage given set of pedigrees known structure and for which family history data may be available. This can applied autosomal X-linked dominant diseases; depending on under consideration, it will often applicable recessive diseases. calculation most usefully undertaken after are gathered, but prior examination testing pedigree members obtain marker information. Of key importance, is straightforward carry out not too time-consuming; practical even microcomputer. The result an objective answer question: Will my families sufficient demonstrate linkage?