Association between microRNA-499 polymorphism and gastric cancer risk in Chinese population
作者： Min Cai , Yitong Zhang , Yanyun Ma , Wenshuai Li , Pei Min
DOI: 10.1016/J.BULCAN.2015.09.012
关键词: microRNA 、 Bioinformatics 、 Case-control study 、 Single-nucleotide polymorphism 、 Genotype 、 Biology 、 Internal medicine 、 Allele 、 Gastroenterology 、 Chinese population 、 Genetic marker 、 SNP
摘要: Single-nucleotide polymorphisms in microRNAs are related to the occurrence, development and prognosis of cancer. The aim present study is investigate possible influence miR-499(rs3746444) polymorphism on risk gastric cancer Chinese population. A total 363 GC patients 969 cancer-free controls were enrolled this study. genotypes obtained using MassARRAY method. results showed that, compared with T allele, C allele was associated a significantly increased (OR=1.491, 95% CI=1.155-1.923, P=0.002). Moreover, subjects TC genotype observed (adjusted OR 1.559, CI=1.148-2.117, P=0.004), wide type TT. We also found that basically dominant model (TT vs. TC+CC) suitable for association between rs6513497 (OR=1.568, CI=1.173-2.097, However, same shown males females. Meanwhile, rs3746444 tumor size patients. indicated miR-499 might contribute SNP could be developed as biomarker prediction.
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sci-hub.se 参考文章(29)
Zhensheng Liu, Guojun Li, Sheng Wei, Jiangong Niu, Adel. K. El-Naggar, Erich M. Sturgis, Qingyi Wei, Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck. Cancer. ,vol. 116, pp. 4753- 4760 ,(2010) , 10.1002/CNCR.25323
Bríd M. Ryan, Ana I. Robles, Curtis C. Harris, Genetic variation in microRNA networks: the implications for cancer research Nature Reviews Cancer. ,vol. 10, pp. 389- 402 ,(2010) , 10.1038/NRC2867
Yanyun Ma, Rui Wang, Jun Zhang, Wenshuai Li, Chunfang Gao, Jie Liu, Jiucun Wang, Identification of miR-423 and miR-499 polymorphisms on affecting the risk of hepatocellular carcinoma in a large-scale population. Genetic Testing and Molecular Biomarkers. ,vol. 18, pp. 516- 524 ,(2014) , 10.1089/GTMB.2013.0510
Mi-die Xu, Lei Dong, Peng Qi, Wei-wei Weng, Xiao-han Shen, Shu-juan Ni, Dan Huang, Cong Tan, Wei-qi Sheng, Xiao-yan Zhou, Xiang Du, Pituitary tumor-transforming gene-1 serves as an independent prognostic biomarker for gastric cancer. Gastric Cancer. ,vol. 19, pp. 107- 115 ,(2016) , 10.1007/S10120-015-0459-2
R. C. Lee, An Extensive Class of Small RNAs in Caenorhabditis elegans Science. ,vol. 294, pp. 862- 864 ,(2001) , 10.1126/SCIENCE.1065329
Xianhui Li, Jiaji Wang, Zhuqing Jia, Qinghua Cui, Chenguang Zhang, Weiping Wang, Ping Chen, Kangtao Ma, Chunyan Zhou, MiR-499 regulates cell proliferation and apoptosis during late-stage cardiac differentiation via Sox6 and cyclin D1. PLOS ONE. ,vol. 8, ,(2013) , 10.1371/JOURNAL.PONE.0074504
BO GUO, JIE LI, LIYING LIU, NI HOU, DONGMIN CHANG, LINGYU ZHAO, ZONGFANG LI, TUSHENG SONG, CHEN HUANG, Dysregulation of miRNAs and their potential as biomarkers for the diagnosis of gastric cancer Biomedical Reports. ,vol. 1, pp. 907- 912 ,(2013) , 10.3892/BR.2013.175
Ondrej Slaby, Julie Bienertova-Vasku, Marek Svoboda, Rostislav Vyzula, Genetic polymorphisms and microRNAs: new direction in molecular epidemiology of solid cancer. Journal of Cellular and Molecular Medicine. ,vol. 16, pp. 8- 21 ,(2012) , 10.1111/J.1582-4934.2011.01359.X
Victor Ambros, The functions of animal microRNAs Nature. ,vol. 431, pp. 350- 355 ,(2004) , 10.1038/NATURE02871
WEI WEI, ZHENG HU, HANJING FU, YI TIE, HAIHONG ZHANG, YONGGE WU, XIAOFEI ZHENG, MicroRNA-1 and microRNA-499 downregulate the expression of the ets1 proto-oncogene in HepG2 cells. Oncology Reports. ,vol. 28, pp. 701- 706 ,(2012) , 10.3892/OR.2012.1850