Identification of miR-423 and miR-499 polymorphisms on affecting the risk of hepatocellular carcinoma in a large-scale population.
作者： Yanyun Ma , Rui Wang , Jun Zhang , Wenshuai Li , Chunfang Gao
关键词: Oncology 、 Bioinformatics 、 Population 、 Hepatitis B 、 Carcinogenesis 、 Hepatocellular carcinoma 、 Single-nucleotide polymorphism 、 Genotype 、 microRNA 、 Odds ratio 、 Internal medicine 、 Biology
摘要: Aims: MicroRNAs (miRNAs) regulate gene expression and act as tumor suppressors or enhancers in oncogenesis. Single-nucleotide polymorphisms (SNPs) miRNAs could alter the processing actions of mature miRNA. So far, association miR-423 rs6505162 with cancers has not been explored, while miR-499 rs3746444 was only reported small-sized samples different types populations. Methods: To evaluate hepatocellular carcinoma (HCC), we performed a large-scale case-control study 984 patients HCC 991 cancer-free controls. Results: The risk significantly higher TC+CC genotypes compared those TT genotype (odds ratio [OR]=1.372, 95% confidence intervals [CI]=1.099–1.713, p=0.005), hepatitis B virus-related (OR=1.437, CI=1.128–1.831, p=0.003). Moreover, subjects were more vulnerable to advanced larger ...
sci-hub.se 参考文章(35)
David P Bartel, MicroRNAs: Genomics, Biogenesis, Mechanism, and Function Cell. ,vol. 116, pp. 281- 297 ,(2004) , 10.1016/S0092-8674(04)00045-5
Hikmet Akkiz, Ersin Akgollu, Oguz Uskudar, Aynur Bekar, Suleyman Bayram, Genetic variation in the microRNA-499 gene and hepatocellular carcinoma risk in a Turkish population: lack of any association in a case-control study. Asian Pacific Journal of Cancer Prevention. ,vol. 12, pp. 3107- 3112 ,(2011)
Xin Lu, Haitao Zhao, Huayu Yang, Yilei Mao, Xinting Sang, Ruoyu Miao, Yiyao Xu, Shunda Du, Haifeng Xu, Tianyi Chi, Zhiying Yang, Shouxian Zhong, Jiefu Huang, A prospective clinical study on early recurrence of hepatocellular carcinoma after hepatectomy Journal of Surgical Oncology. ,vol. 100, pp. 488- 493 ,(2009) , 10.1002/JSO.21354
Zhensheng Liu, Guojun Li, Sheng Wei, Jiangong Niu, Adel. K. El-Naggar, Erich M. Sturgis, Qingyi Wei, Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck. Cancer. ,vol. 116, pp. 4753- 4760 ,(2010) , 10.1002/CNCR.25323
Linhui Liang, Chun-Ming Wong, Qiao Ying, Dorothy Ngo-Yin Fan, Shenglin Huang, Jie Ding, Jian Yao, Mingxia Yan, Jinjun Li, Ming Yao, Irene Oi-Lin Ng, Xianghuo He, MicroRNA‐125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2 Hepatology. ,vol. 52, pp. 1731- 1740 ,(2010) , 10.1002/HEP.23904
Jing Guo, Mingjuan Jin, Mingwu Zhang, Kun Chen, A Genetic Variant in miR-196a2 Increased Digestive System Cancer Risks: A Meta-Analysis of 15 Case-Control Studies PLoS ONE. ,vol. 7, pp. e30585- ,(2012) , 10.1371/JOURNAL.PONE.0030585
Yu Xiang, Song Fan, Ju Cao, Shifeng Huang, Li-ping Zhang, Association of the microRNA-499 variants with susceptibility to hepatocellular carcinoma in a Chinese population Molecular Biology Reports. ,vol. 39, pp. 7019- 7023 ,(2012) , 10.1007/S11033-012-1532-0
George A. Calin, Carlo M. Croce, MicroRNA signatures in human cancers Nature Reviews Cancer. ,vol. 6, pp. 857- 866 ,(2006) , 10.1038/NRC1997
Carlo M. Croce, Causes and consequences of microRNA dysregulation in cancer Nature Reviews Genetics. ,vol. 10, pp. 704- 714 ,(2009) , 10.1038/NRG2634
WEI WEI, ZHENG HU, HANJING FU, YI TIE, HAIHONG ZHANG, YONGGE WU, XIAOFEI ZHENG, MicroRNA-1 and microRNA-499 downregulate the expression of the ets1 proto-oncogene in HepG2 cells. Oncology Reports. ,vol. 28, pp. 701- 706 ,(2012) , 10.3892/OR.2012.1850