Recognition of self and regulation of specificity at the level of cell populations.

摘要: It is suggested that immunologic specificity and selective responsiveness, assayed by effector memory cells, are, in part, determined the existing repertoire of lymphocytes and, dynamic nature cellular growth. Clones within horizontal networks resemble competing species a Darwinian world. Upon stimulation, development clone greatly affected, way, factors determine balance between self-renewal differentiation. Antigen major factor. The amount antigen encounter with immune system (sudden, graded or continuous), through selection particular subset clones, can be correlated weak strong expression function generation effective tolerance. self antigens obeys same rules. Thus, distinction non-self quantitative one, both at single-cell level systemic level. developing antigens, idiotypes MHC-antigens, restricts imposes constraints on mode interaction foreign potential self-recognition networks. proposed "dynamic scheme", differing from "structural schemes" number fundamental aspects, calls for reevaluation present concepts immunoregulation reinterpretation data.