Safety assessment of saponins extract in Dolichos falcatus Klein: Subchronic study in Sprague-Dawley rats.

摘要: Abstract Ethnopharmacological relevance Dolichos falcatus Klein (DF), a Chinese Dai ethnic medicine popularly known as “Tuoyeteng” in Yunnan province of China, has been widely used China to treat fracture, rheumatoid arthritis and soft tissue injuries for long time. Our previous study showed that saponins DF (DFS) ameliorated the gouty induced by MSU crystals vivo vitro. The present was carried out evaluate no-observed-adverse-effect level (NOAEL) DFS. Materials methods Sprague-Dawley rats (10/sex/group) were gavaged with DFS at dose 0, 50, 100 200 mg/kg body weight /day 90-days. Results administration did not result mortality or show treatment-related changes clinical signs toxicity, weights gain feed consumption. Similarly, addition slightly hemolytic anemia gastrointestinal tract lesion males high-dose treatment group, no toxicologically significant hematological, chemistry, urine analysis parameters, organ weights, macroscopic microscopic abnormalities noted during testing period. Conclusion results subchronic toxicity support NOAEL 200 mg/kg/d females 100 mg/kg/d males. These provide an important reference further DFS-related trials new drug exploration.