A 90-day subchronic toxicological assessment of dioscin, a natural steroid saponin, in Sprague-Dawley rats.

摘要: Dioscin is the major active compound in many traditional Chinese medicines (TCMs), while safety evaluation of this natural product has not yet been investigated. Therefore, aim study was to evaluate 90-day subchronic toxicity dioscin rats. The rats were divided into four groups and administered orally at doses 0, 75, 150 300 mg/kg/day, respectively. evaluated based on clinical observations, ophthalmic examination, body weight, food water consumption, urinalysis, hematology, biochemistry pathology. results showed that had no female slight male However, mg/kg/day group gastro-intestinal tract distension during treatment period hemolytic anemia hematology assessment. Compared with control group, weight gain significantly decreased Other significant changes associated groups. In conclusion, no-observed-adverse-effect level (NOAEL) lowest-observed-adverse-effect (LOAEL) are estimated be for rats, Our work provides useful data further research new drug exploration dioscin.