Genomic and Proteomic Analysis Reveals a Threshold Level of MYC Required for Tumor Maintenance
作者： Catherine M. Shachaf , Andrew J. Gentles , Sailaja Elchuri , Debashis Sahoo , Yoav Soen
DOI: 10.1158/0008-5472.CAN-07-6192
关键词: Carcinogenesis 、 Regulation of gene expression 、 Gene expression profiling 、 Cancer research 、 Gene expression 、 Biology 、 Proto-Oncogene Proteins c-myc 、 Cell cycle checkpoint 、 Cell sorting 、 Cell cycle
摘要: MYC overexpression has been implicated in the pathogenesis of most types of human cancers. MYC is likely to contribute to tumorigenesis by its effects on global gene …
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Omar D. Perez, Peter O. Krutzik, Garry P. Nolan, Flow Cytometric Analysis of Kinase Signaling Cascades Methods of Molecular Biology. ,vol. 263, pp. 67- 94 ,(2004) , 10.1385/1-59259-773-4:067
Celina M. D'Cruz, Edward J. Gunther, Robert B. Boxer, Jennifer L. Hartman, Louis Sintasath, Susan E. Moody, James D. Cox, Seung I. Ha, George K. Belka, Alexander Golant, Robert D. Cardiff, Lewis A. Chodosh, c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations Nature Medicine. ,vol. 7, pp. 235- 239 ,(2001) , 10.1038/84691
Dean W. Felsher, Cancer revoked: oncogenes as therapeutic targets Nature Reviews Cancer. ,vol. 3, pp. 375- 379 ,(2003) , 10.1038/NRC1070
Carla Grandori, Natividad Gomez-Roman, Zoe A. Felton-Edkins, Celine Ngouenet, Denise A. Galloway, Robert N. Eisenman, Robert J. White, c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I. Nature Cell Biology. ,vol. 7, pp. 311- 318 ,(2005) , 10.1038/NCB1224
Jonathan M Irish, Randi Hovland, Peter O Krutzik, Omar D Perez, Øystein Bruserud, Bjørn T Gjertsen, Garry P Nolan, Single Cell Profiling of Potentiated Phospho-Protein Networks in Cancer Cells Cell. ,vol. 118, pp. 217- 228 ,(2004) , 10.1016/J.CELL.2004.06.028
Catherine M. Shachaf, Omar D. Perez, Sawsan Youssef, Alice C. Fan, Sailaja Elchuri, Matthew J. Goldstein, Amy E. Shirer, Orr Sharpe, Joy Chen, Dennis J. Mitchell, Maria Chang, Garry P. Nolan, Lawrence Steinman, Dean W. Felsher, Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis Blood. ,vol. 110, pp. 2674- 2684 ,(2007) , 10.1182/BLOOD-2006-09-048033
Meenakshi Jain, Constadina Arvanitis, Kenneth Chu, William Dewey, Edith Leonhardt, Maxine Trinh, Christopher D Sundberg, J Michael Bishop, Dean W Felsher, Sustained Loss of a Neoplastic Phenotype by Brief Inactivation of MYC Science. ,vol. 297, pp. 102- 104 ,(2002) , 10.1126/SCIENCE.1071489
Kok-Lung Chan, Xin-Yuan Guan, Irene Oi-Lin Ng, High-throughput tissue microarray analysis of c-myc activation in chronic liver diseases and hepatocellular carcinoma Human Pathology. ,vol. 35, pp. 1324- 1331 ,(2004) , 10.1016/J.HUMPATH.2004.06.012
Ana-Isabel Sáez, María-Jesús Artiga, Cristina Romero, Sandra Rodríguez, Juan-Cruz Cigudosa, Alberto Pérez-Rosado, Isabel Fernández, Margarita Sánchez-Beato, Esther Sánchez, Manuela Mollejo, Miguel Á Piris, Development of a Real-Time Reverse Transcription Polymerase Chain Reaction Assay for c-myc Expression That Allows the Identification of a Subset of c-myc+ Diffuse Large B-Cell Lymphoma Laboratory Investigation. ,vol. 83, pp. 143- 152 ,(2003) , 10.1097/01.LAB.0000057000.41585.FD
Ernesto Guccione, Francesca Martinato, Giacomo Finocchiaro, Lucilla Luzi, Laura Tizzoni, Valentina Dall' Olio, Giuseppe Zardo, Clara Nervi, Loris Bernard, Bruno Amati, Myc-binding-site recognition in the human genome is determined by chromatin context Nature Cell Biology. ,vol. 8, pp. 764- 770 ,(2006) , 10.1038/NCB1434