Variables influencing penicillin treatment outcome in streptococcal tonsillopharyngitis

摘要: Objective To examine whether penicillin treatment success for group A β-hemolytic streptococcal tonsillopharyngitis is influenced by patient age, number of days ill prior to initiation treatment, episodes, season, total dosage (milligrams per kilogram), and frequency administration (2 vs 3 times daily). Methods Four hundred seventy-eight children, adolescents, young adults aged 2 21 years with acute symptoms compatible the clinical diagnosis a positive streptococcus rapid antigen detection test result were enrolled (intent-to-treat group). Patients randomly assigned receive V potassium, 250 mg daily (n=239) or 500 (n=239). Randomization was independent body weight 10 both regimens. Follow-up examinations occurred, cultures obtained at 14 after antibiotic therapy; those isolated from throat culture who returned follow-up assessed outcome (n=359). Results Using logistic regression analysis stepwise variable selection, we found major variables associated be ( P =.001; odds ratio, 1.55 [95% confidence interval, 1.2-2.1]) age child when infected =.004; 1.14 1.05-1.25]). The episodes within preceding year, dose (range, 8-76 mg/kg), dosing did not significantly alter outcome. Conclusion Treatment illness adolescent patients increases tonsillopharyngitis.