Amygdaloid kindling is anxiogenic but fails to alter object recognition or spatial working memory in rats

摘要: Kindling in rats produces enduring behavioral changes that parallel the psychobehavioral disturbances frequently accompanying temporal lobe epilepsy. Some evidence suggests site of kindling is an important determinant type observed following kindling, although this variable has not been systematically investigated. In present experiments, effects amygdaloid were assessed on a battery tests we used previously to assess dorsal hippocampus or perirhinal cortex. Three generalized seizures kindled with stimulation near basolateral amygdala. One week later, tested successively measures anxiety, activity, object recognition memory, and spatial working memory over period 3 weeks. Amygdaloid produced increased but spared all other behaviors assessed. This pattern results partially distinct from described cortical which increases anxiety also impairs completely hippocampal selectively activity memory. The observations suggest highly interconnected sites patterns comorbidity. underlying mechanisms are thus most likely localized intrinsic circuits at seizure origination.