Histologic Findings One Year After Positive Crossmatch or ABO Blood Group Incompatible Living Donor Kidney Transplantation

摘要: Recent protocols have allowed successful positive crossmatch (+XM) and ABO incompatible (ABOI) kidney transplantation, although their long-term outcome is not clear. To begin to assess this issue we compared protocol biopsies performed 12 months posttransplant in 37 +XM, 24 ABOI 198 conventional allografts. Although the majority all three groups had only minimal histologic changes, transplant glomerulopathy (TG) was significantly increased +XM (22% vs. 13% 8% conventional, p = 0.015), correlated with prior humoral rejection (HR) by multivariate analysis (odds ratio 17.5, < or 0.0001). Patients a history of HR also significant increase interstitial fibrosis (No 54% 86%, 0.045). In absence no difference changes seen between groups, demonstrable mild from at time transplant. Thus, associated an TG, its allograft histology similar allografts 1 year posttransplant.