Comparison of angiographic and IVUS derived coronary geometric reconstructions for evaluation of the association of hemodynamics with coronary artery disease progression

摘要: Wall shear stress (WSS) has been investigated as a prognostic marker for the prospective identification of rapidly progressing coronary artery disease (CAD) and atherosclerotic lesions likely to gain high-risk (vulnerable) characteristics. The goal this study was compare biplane angiographic vs. intravascular ultrasound (IVUS) derived reconstructed geometries evaluate agreement in geometry, computed WSS, association WSS CAD progression. Baseline 6-month follow-up IVUS imaging data were collected patients with non-obstructive (n = 5). Three-dimensional (3D) reconstructions arteries generated each technique, patient-specific computational fluid dynamics models constructed compute baseline values. Geometric comparisons evaluated arterial segments (n = 9), hemodynamic circumferential sections (n = 468). progression quantified from serial (n = 277), included virtual-histology (VH-IVUS) changes plaque composition. There no significant difference segment lengths cross-sectional areas (CSA), however, exhibited significantly larger left main CSA than reconstructions. Computed absolute time-averaged (TAWSSABS) values greater geometries, evaluations relative TAWSS (TAWSSREL) revealed improved differences within defined zones equivalence. Associations between VH-IVUS or poor when examining TAWSSABS data, but evaluating TAWSSREL data. We present small cohort highlighting strong limited is observed associations