The Effects That Cardiac Motion has on Coronary Hemodynamics and Catheter Trackability Forces for the Treatment of Coronary Artery Disease: An In Vitro Assessment

摘要: The coronary arterial tree experiences large displacements due to the contraction and expansion of cardiac muscle may influence haemodynamics stent placement. accurate measurement catheter trackability forces within physiological relevant test systems is required for optimum design. effects motion on flowrates, pressure drops, delivery has not been previously experimentally assessed. A simulator was designed manufactured which replicates flowrates a patient-specific geometry. motorized system delivered commercially available monitored along three phantom thin walled compliant vessels supported by dynamic model. Pressure drop variation more sensitive than outlet flowrates. Maximum drops varied from 7 49 mmHg stenosis % area reduction 56 90%. There strong positive linear correlation cumulative force with curvature. maximum curvature ranged 0.24 0.87 N 0.06 0.22 mm−1 respectively all vessels. were average percentage differences in (23–49%) (1.9–5.2%) when comparing static case inclusion pulsatile flow motion. Cardiac significantly altered (p value <0.001) pathways high local variations measurements.