SARS-CoV-2 Infection and Lung Cancer: Potential Therapeutic Modalities.

摘要: Human coronaviruses, especially SARS-CoV-2, are emerging pandemic infectious diseases with high morbidity and mortality in certain group of patients. In general, SARS-CoV-2 causes symptoms ranging from the common cold to severe conditions accompanied by lung injury, acute respiratory distress syndrome addition other organs' destruction. The main impact upon infection is damage alveolar failure. Thus, cancer patients identified as a particularly high-risk for its complications. On hand, it has been reported that spike (S) protein binds angiotensin-converting enzyme 2 (ACE-2), promotes cellular entry this virus concert host proteases, principally transmembrane serine protease (TMPRSS2). Today, there no vaccines and/or effective drugs against coronavirus. manipulation key genes could be one best approaches manage We herein provide comprehensive up-to-date overview role ACE-2 TMPRSS2 genes, elements well therapeutic targets infection, which can help better understand applications capacities various remedial infected individuals, those cancer.