Managing hematologic toxicities.

作者: Roger Waltzman , Gerardo Capo

DOI:

关键词: Clinical significanceIntensive care medicineNeutropeniaDrugChemotherapyEvidence-based medicineClinical trialMedicineBlood transfusionImmunologyAnemia

摘要: This overview of the hematologic toxicities cancer chemotherapy addresses frequency and clinical significance neutropenia, anemia, thrombocytopenia attempts to provide evidence-based guidelines, based on trials, for use cytokine growth factors transfusion support. The current emphasis high-dose dose-dense increases need close attention amelioration ofhematologic toxicities. latter is highly dependent upon appropriate judicious Although these supportive agents may be relatively nontoxic, it important understand their potential side effects them only when warranted by studies.

参考文章(60)
Carole B. Miller, Richard J. Jones, Steven Piantadosi, Martin D. Abeloff, Jerry L. Spivak, Decreased Erythropoietin Response in Patients with the Anemia of Cancer New England Journal of Medicine. ,vol. 322, pp. 1689- 1692 ,(1990) , 10.1056/NEJM199006143222401
Jeffrey Crawford, Howard Ozer, Ronald Stoller, David Johnson, Gary Lyman, Imad Tabbara, Mark Kris, John Grous, Vincent Picozzi, Gregory Rausch, Roy Smith, William Gradishar, Anne Yahanda, Martha Vincent, Morgan Stewart, John Glaspy, Reduction by Granulocyte Colony-Stimulating Factor of Fever and Neutropenia Induced by Chemotherapy in Patients with Small-Cell Lung Cancer New England Journal of Medicine. ,vol. 325, pp. 164- 170 ,(1991) , 10.1056/NEJM199107183250305
N. Simon Tchekmedyian, John A. Glaspy, Darbepoetin alfa administered every 2 weeks alleviates anemia in cancer patients receiving chemotherapy. Oncology. ,vol. 16, pp. 23- 29 ,(2002)
N Simon Tchekmedyian, Anemia in cancer patients: significance, epidemiology, and current therapy. Oncology. ,vol. 16, pp. 17- 24 ,(2002)
G. Richard Lee ..., Wintrobe's Clinical Hematology ,(1981)
Joseph W. Eschbach, Michael R. Kelly, N. Rebecca Haley, Robert I. Abels, John W. Adamson, Treatment of the anemia of progressive renal failure with recombinant human erythropoietin. The New England Journal of Medicine. ,vol. 321, pp. 158- 163 ,(1989) , 10.1056/NEJM198907203210305
Robert Turner, Peter Anglin, Ronald Burkes, Félix Couture, William Evans, Glenwood Goss, Robert Grimshaw, Barbara Melosky, Alexander Paterson, Ian Quirt, Epoetin alfa in cancer patients: evidence-based guidelines Journal of Pain and Symptom Management. ,vol. 22, pp. 954- 965 ,(2001) , 10.1016/S0885-3924(01)00357-8
Umberto Veronesi, Herbert Pinedo, Michael Peckham, Oxford textbook of oncology Biomedicine & Pharmacotherapy. ,vol. 2, pp. 95- ,(1996)
Robert T Dorr, Daniel D Von Hoff, Cancer chemotherapy handbook ,(1980)