Translational Research: Walking the Bridge between Idea and Cure—Seventeenth Bruce F. Cain Memorial Award Lecture

摘要: Advances in the understanding of normal and malignant cell biology are allowing development biologically targeted drugs directed at specific differences between host tumor. The array potential new targets is vast, but currently cell-cycle regulators, growth factors their receptors, signal transduction intermediates, angiogenesis, mechanisms that mediate apoptosis DNA repair. Recent results raise possibility novel agents, perhaps combination with traditional cytotoxic may finally cure cancer. However, a drug raises unique challenges design clinical trials to demonstrate its efficacy, despite promising preclinical data exist for most agents development, trial remains critical, final step across bridge from basic research application. In this review, we discuss some implications design.