From bench to bedside: the growing use of translational research in cancer medicine

摘要: Cancer is responsible for one in eight deaths worldwide, with more than twelve million new cases diagnosed yearly. A large percentage of patients die after developing cancer despite aggressive treatment, indicating a need approaches to therapy. The push development novel diagnostic and therapeutic agents has allowed translational research flourish. Genomic proteomic technologies have generated an enormous amount information critical expanding our understanding biology. New on the differences between normal malignant cell biology paved way drugs targeted specific biological molecules, potentially increasing antitumor efficacy while minimizing toxicity patient that seen conventional therapeutics. Current targets include regulators cycle, angiogenesis, apoptosis, DNA repair, growth factors their receptors. Collaboration among researchers, clinicians, pharmaceutical companies vital conducting clinical trials translate laboratory findings into clinically applicable In this review, we discuss current present introduction wide range topics undergoing investigation effort highlight importance relevant strategies.