Mitotic Regulator Hec1 as a Potential Target for Cancer Therapy

摘要: Studies on mitosis have provided abundant molecular and biochemical insights into this highly complex stage of the cell cycle. During mitosis, cells employ a multitude factors to orchestrate spindle formation chromosome movement in coordination with proper checkpoint control. Functional perturbation or inactivation these mitotic regulators often triggers abnormal progression, which may consequently lead catastrophe death. Because cancer are proliferative, disruption has become useful strategy for therapeutic intervention. One important regulator, Hec1 (highly expressed 1), plays an essential role progression through its function assembly. Our laboratory developed small molecule inhibitors (INH) that disrupt interaction between Nek2. Treatment compounds leads drastic abnormalities segregation, assembly, eventual Importantly, INH inhibits tumor growth nude mouse model no adverse side effects. results demonstrate novel method cell-specific inhibition by innovative class warrant further development.