New depths in cell behaviour: reactions of cells to nanotopography.

摘要: The physical and molecular biological bases of the reactions cells to features topography substratum or environment on which in live, both culture embryo, are discussed. fact that most, if not all, react micrometric nanometric is stressed. Some cell types will steps as shallow 11 nm. Methods fabricating such topographies a variety materials outlined. Types these described. It emphasized different sensitive fairly specific ranges size topography. Reactions include orientation, changes motility, adhesion shape. term 'contact guidance' has been used this field, but 'topographic reaction' more appropriate, since it covers wide range reported. In addition, involve activation tyrosine kinases, cytoskeletal condensation further downstream inactivation gene expression. probably due stretch chemical details substratum. reasons for given type reacts much same way made with that, when patterns topographic ones offered cells, tends have greater effect than patterns.