Suppression of tumor growth through disruption of hypoxia-inducible transcription.
作者： Andrew L. Kung , Stream Wang , Jeffery M. Klco , William G. Kaelin , David M. Livingston
DOI: 10.1038/82146
关键词: Regulation of gene expression 、 Angiogenesis 、 Hypoxia (medical) 、 Transcription factor 、 Tumor progression 、 Molecular biology 、 Gene expression 、 CREB-binding protein 、 Cancer research 、 HIF1A 、 Biology
摘要: Chronic hypoxia, a hallmark of many tumors, is associated with angiogenesis and tumor progression. Strategies to treat tumors have been developed in which cells are targeted drugs or gene-therapy vectors specifically activated under hypoxic conditions. Here we report different approach, the normal transcriptional response hypoxia selectively disrupted. Our data indicate that specific blockade interaction hypoxia-inducible factor CH1 domain its p300 CREB binding protein coactivators leads attenuation gene expression diminution growth. Thus, disrupting co-activational may be new useful therapeutic strategy.
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