Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation.
作者： Gabriel Helmlinger , Fan Yuan , Marc Dellian , Rakesh K. Jain
DOI: 10.1038/NM0297-177
关键词:
摘要: The partial pressure of oxygen (pO 2 ) and pH play critical roles in tumor biology and therapy. We report here the first combined, high-resolution (≤10 μm) measurements of interstitial …
nature.com
springer.com
sci-hub.se 参考文章(46)
I. P. Torres Filho, M. Intaglietta, Microvessel PO2 measurements by phosphorescence decay method American Journal of Physiology-heart and Circulatory Physiology. ,vol. 265, ,(1993) , 10.1152/AJPHEART.1993.265.4.H1434
Herman Suit, Tumor Oxygenation and Radiosensitivity Birkhäuser Boston. pp. 187- 199 ,(1995) , 10.1007/978-1-4612-2576-8_13
Alwin E. Goetz, Fan Yuan, Yves Boucher, Rakesh K. Jain, Konrad Messmer, Michael Leunig, Michael D. Menger, Angiogenesis, Microvascular Architecture, Microhemodynamics, and Interstitial Fluid Pressure during Early Growth of Human Adenocarcinoma LS174T in SCID Mice Cancer Research. ,vol. 52, pp. 6553- 6560 ,(1992)
Leo E. Gerweck, Kala Seetharaman, Cellular pH gradient in tumor versus normal tissue : Potential exploitation for the treatment of cancer Cancer Research. ,vol. 56, pp. 1194- 1198 ,(1996)
Wataru Kamiike, Yoshihide Tsujimoto, Yutaka Eguchi, Hikaru Matsuda, Shigeomi Shimizu, Yoshinori Otsuki, Kazuo Yamabe, Yuko Itoh, Jun-ichi Hasegawa, Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bcl-XL. Cancer Research. ,vol. 56, pp. 2161- 2166 ,(1996)
Koch Cj, Lord Em, Evans Sm, Jenkins Wt, Joiner B, 2-Nitroimidazole (EF5) Binding Predicts Radiation Resistance in Individual 9L s.c. Tumors Cancer Research. ,vol. 56, pp. 405- 411 ,(1996)
Kolbein Sundfør, Stefan Walenta, Einar K. Rofstad, George Schwickert, Wolfgang Mueller-Klieser, Correlation of High Lactate Levels in Human Cervical Cancer with Incidence of Metastasis Cancer Research. ,vol. 55, pp. 4757- 4759 ,(1995)
H. Acker, T. Nederman, T. Nylén, J. Carlsson, G. Holtermann, Influence of Glucose and Buffer Capacity in the Culture Medium on Growth and pH in Spheroids of Human Thyroid Carcinoma and Human Glioma Origin Cancer Research. ,vol. 47, pp. 3504- 3508 ,(1987)
Jain Rk, Martin Gr, Noninvasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy. Cancer Research. ,vol. 54, pp. 5670- 5674 ,(1994)
R. M. Sutherland, W. Mueller-Klieser, B. Sordat, J. Bamat, H. Gabbert, B. Bourrat, Oxygenation and differentiation in multicellular spheroids of human colon carcinoma. Cancer Research. ,vol. 46, pp. 5320- 5329 ,(1986)