Transparent Window Models and Intravital Microscopy

摘要: The past 30 years have witnessed spectacular advances in our understanding of the molecular origins cancer and other diseases. These led to identification various genes associated with angiogenesis oncogenesis, development a vast array therapeutic agents. grand challenges now are relate expression these their function an intact organism, deliver novel therapeutics targets vivo (70). Currently, gene expression, physiological function, drug delivery usually measured techniques that either destructive or poor spatial resolution (millimeter centimeter). former limited ability provide insight into dynamics, latter preclude visualization at cellular subcellular levels (1–10 µm).