Microenvironmental Effects on Tumour Progression and Metastasis
作者： Kårstein Måseide , Tuula Kalliomäki , Richard P. Hill
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摘要: The microenvironment of a tumour differs significantly from that normal tissue due to abnormal vasculature and altered cellular metabolism in tumours. Microenvironmental conditions tumours, which include hypoxia, acidity, nutrient deprivation high interstitial fluid pressure, have been associated with metastatic progression both experimentally clinically. mechanisms by this occurs are believed genomic instability, changes gene expression levels microenvironment-mediated selective pressure. These modify cell survival growth during the angiogenic, migratory invasive stages metastasis. This chapter summarises data examining links between metastasis discusses possibility using microenvironmentally regulated genes as intrinsic prognostic markers.
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