Proliferation and Remodeling of the Peritubular Microcirculation after Nephron Reduction : Association with the Progression of Renal Lesions

摘要: Little is known about the serial changes that might occur in renal capillaries after reduction of mass. In current study, our aim was to document potential alterations morphology and proliferation cortical peritubular microcirculation at specific time points (7 60 days) experimental 75% surgical nephron using two strains mice we here demonstrate react differently same initial insult: one strain (C57BL6xDBA2/F1 mice) undergoes compensatory growth alone, whereas other (FVB/N additionally develops severe tubulo-interstitial lesions. Our data significant remodeling reduction, as assessed by microangiography infusion fluorescein isothiocyanate-labeled dextran, expression endothelial markers CD34 Tie-2, co-expression proliferating cell nuclear antigen, a surrogate marker proliferation. This accompanied an increase vascular factor protein levels change distribution this within kidney itself. Moreover, most these responses were accentuated FVB/N presence progressive disease positively correlated with tubular epithelial Hence, have made three novel observations illuminate complex pathophysiology chronic damage reduction: 1) grow remodeling, 2) altered, 3) development genetically determined.