Protection against carbon tetrachloride-induced hepatotoxicity by pretreatment with methylmercury hydroxide.
作者： Gary P. Carlson
DOI: 10.1016/0300-483X(75)90024-4
关键词: Pharmacology 、 Carbon tetrachloride 、 Sorbitol dehydrogenase 、 Metabolism 、 CCL4 、 Transaminase 、 Demethylation 、 Lipid metabolism 、 Biochemistry 、 Lipid peroxidation 、 Chemistry
摘要: Pretreatment of rats with methylmercury hydroxide (MMH) (15 mg/kg s.c. for 2 days) protected against hepatotoxicity due to the inhalation CCl4 vapor (4800-6100 ppm h). This was evidenced by lessening changes in liver glucose-6-phosphatase, serum glutamic oxalacetic transaminase (SGOT), pyruvic (SGPT), isocitrate dehydrogenase and sorbitol dehydrogenase. Decreases p-nitroanisole demethylation cytochrome P-450 were also altered. Lipid peroxidation decreased MMH. These biochemical indices protection supported histopathological observations. results lend further support concept that metabolism is necessary its hepatoxicity.
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