Influence of starvation on the induction of xenobiotic metabolism by polychlorinated biphenyls
作者： Gary P. Carlson
DOI: 10.1016/0024-3205(80)90566-4
关键词: Adipose tissue 、 Cytochrome 、 Polychlorinated biphenyl 、 Demethylation 、 Endocrinology 、 Biochemistry 、 Enzyme assay 、 Detoxification 、 Metabolism 、 Chemistry 、 Drug metabolism 、 Internal medicine 、 General Pharmacology, Toxicology and Pharmaceutics 、 General Biochemistry, Genetics and Molecular Biology 、 General Medicine
摘要: The administration of a commercial polychlorinated biphenyl mixture, Aroclor 1254, at dose 10 mg/kg/day po for 14 days to rats resulted in increases EPN detoxification, p-nitroanisole demethylation, NADPH cytochrome c reductase and P-450 which persisted up four five months. Starvation prior making these determinations caused an enhancement this induction. This interaction may be due mobilization PCBs from storage sites adipose tissue.
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