AKRs expression in peripheral blood lymphocytes from smokers: the role of body mass index.

摘要: Aldo-keto reductases (AKRs) metabolize a wide range of substrates, including polycyclic aromatic hydrocarbons (PAHs), generating metabolites (o-quinones) and reactive oxygen species (ROS), which are capable initiating promoting carcinogenesis. Exposure to PAHs, their metabolites, ROS further increase AKRs isoform expression that may amplify oxidative damage. Human AKR enzymes highly polymorphic, allelic variants contribute different in individuals. Despite the importance PAHs metabolism, there no studies evaluate, general human populations, effect on peripheral blood lymphocytes (PBLs). The aim this study was determine tobacco smoke exposure, AKR1A1*2 AKR1C3*2 polymorphisms, AKR1A1 AKR1C1-AKR1C3 messenger RNA (mRNA) levels PBLs from smokers. In smoker group, is statistically significant positive association between AKR1A1, AKR1C1, AKR1C3 mRNA induction urine cotinine individuals with body mass index (BMI) less than 25. However, alleles did not influence levels. These results suggest by smokers' associated BMI; therefore, role adipose tissue accumulation PAHs' effects needs investigation.