1,3-Dipolar cycloaddition of nitrilimines to 2,4-disubstituted-3H-1, 5-benzodiazepines: remarkable effect of C4-substituent on diastereoselectivity
作者： Khadija Nabih , Abdesselam Baouid , Aissa Hasnaoui , Mohamed Selkti , Philippe Compain
DOI: 10.1039/B303995C
关键词: 1,3-Dipolar cycloaddition 、 Stereochemistry 、 Cycloaddition 、 Substituent 、 Chemistry
摘要: The one-step synthesis of new bis[1,2,4-triazolo][4,3-a:3′,4′-d][1,5] benzodiazepines by way completely regio- and diastereoselective 1,3-dipolar cycloaddition nitrilimines to 2,4-dimethyl-3H-1,5-benzodiazepines is reported a tentative rationalization for the observed diastereoselectivity, which underline key effect C4-dipolarophile substituent, proposed.
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