1,5-Dimethyl-3-[(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)meth-yl]-1H-1,5-benzodiazepine-2,4(3H,5H)-dione.
作者： Rachida Dardouri , Youssef Kandri Rodi , Nathalie Saffon , Lahcen El Ammari , El Mokhtar Essassi
DOI: 10.1107/S1600536810042972
关键词:
摘要: The reaction of 3-allyl-1,5-dimethyl-1,5-benzodiazepine-2,4-dione and benzaldoxime leads to the title compound, C21H21N3O3. molecular structure is built up from two fused six- seven-membered rings linked a chain including five- six-membered ring (isoxazoline phenyl) via methylene group. displays boat conformation. dihedral angle between 74.3 (1)°.
sci-hub.se 参考文章(13)
Rajesh G. Kalkhambkar, Geeta M. Kulkarni, Chandrappa M. Kamanavalli, N. Premkumar, S.M.B. Asdaq, Chung Ming Sun, Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins European Journal of Medicinal Chemistry. ,vol. 43, pp. 2178- 2188 ,(2008) , 10.1016/J.EJMECH.2007.08.007
Stacey J. Sukoff, Qian Lin, Corey N. Bender, Bart W. Nieuwenhuijsen, Robert H. Ring, Lee E. Schechter, Sharon Rosenzweig-Lipson, Chad E. Beyer, S. Johannes R. Rajarao, Brian Platt, Anxiolytic-like activity of the non-selective galanin receptor agonist, galnon Neuropeptides. ,vol. 41, pp. 307- 320 ,(2007) , 10.1016/J.NPEP.2007.05.001
Khadija Nabih, Abdesselam Baouid, Aissa Hasnaoui, Mohamed Selkti, Philippe Compain, 1,3-Dipolar cycloaddition of nitrilimines to 2,4-disubstituted-3H-1, 5-benzodiazepines: remarkable effect of C4-substituent on diastereoselectivity New Journal of Chemistry. ,vol. 27, pp. 1644- 1648 ,(2003) , 10.1039/B303995C
A. Keita, F. Lazrak, E. M. Essassi, I. Cherif Alaoui, Y. Kandri Rodi, J. Bellan, M. Pierrot, 2,4-Dioxo(dimercapto)-1,5-benzodiazepino-13-couronne-2, Nouveau Macrocycle Complexant de L'ion Ag + Phosphorus Sulfur and Silicon and The Related Elements. ,vol. 178, pp. 1541- 1548 ,(2003) , 10.1080/10426500307884
Richard H. Smith,, William L. Jorgensen, Julian Tirado-Rives, Michelle L. Lamb, Paul A. J. Janssen, Christopher J. Michejda, Marilyn B. Kroeger Smith, Prediction of binding affinities for TIBO inhibitors of HIV-1 reverse transcriptase using Monte Carlo simulations in a linear response method. Journal of Medicinal Chemistry. ,vol. 41, pp. 5272- 5286 ,(1998) , 10.1021/JM9804174
L. J. Farrugia, ORTEP-3 for Windows - a version of ORTEP-III with a Graphical User Interface (GUI) Journal of Applied Crystallography. ,vol. 30, pp. 565- 565 ,(1997) , 10.1107/S0021889897003117
Louis J. Farrugia, WinGX suite for small-molecule single-crystal crystallography Journal of Applied Crystallography. ,vol. 32, pp. 837- 838 ,(1999) , 10.1107/S0021889899006020
K. Vishnu Vardhan Reddy, P. Sampath Rao, D. Ashok, A Facile Synthesis of 2-Benzoyl-6-Hydroxy-3-Methyl-5-(2-Substituted-2,3-Dihydro-1H-1,5-Benzodiazepin-4-YL) Benzo[b]Furans Synthetic Communications. ,vol. 30, pp. 1825- 1836 ,(2000) , 10.1080/00397910008087228
Paolo Fruscella, Marcello Sottocorno, Mario Di Braccio, Luisa Diomede, Nicola Piccardi, Alfredo Cagnotto, Giancarlo Grossi, Maria Romano, Tiziana Mennini, Giorgio Roma, 1,5-Benzodiazepine tricyclic derivatives exerting anti-inflammatory effects in mice by inhibiting interleukin-6 and prostaglandinE2production Pharmacological Research. ,vol. 43, pp. 445- 451 ,(2001) , 10.1006/PHRS.2001.0800
Gabriella Guerrini, Annarella Costanzo, Giovanna Ciciani, Fabrizio Bruni, Silvia Selleri, Camilla Costagli, François Besnard, Barbara Costa, Claudia Martini, Gaetano De Siena, Petra Malmberg-Aiello, Benzodiazepine receptor ligands. 8: synthesis and pharmacological evaluation of new pyrazolo[5,1-c] [1,2,4]benzotriazine 5-oxide 3- and 8-disubstituted: high affinity ligands endowed with inverse-agonist pharmacological efficacy. Bioorganic & Medicinal Chemistry. ,vol. 14, pp. 758- 775 ,(2006) , 10.1016/J.BMC.2005.08.058