Intermittent hypoxia training in prediabetes patients: Beneficial effects on glucose homeostasis, hypoxia tolerance and gene expression.

摘要: The present study aimed at examining beneficial effects of intermittent hypoxia training (IHT) under prediabetic conditions. We investigate the three-week IHT on blood glucose level, tolerance to acute hypoxia, and leukocyte mRNA expression inducible factor 1α (HIF-1α) its target genes, i.e. insulin receptor, facilitated transporter-solute carrier family-2, potassium voltage-gated channel subfamily J. Seven healthy 11 men women (44-70 years age) were examined before, next day one month after (3 sessions per week, each session consisting 4 cycles 5-min 12% O2 room air breathing). found that afforded homeostasis in patients with prediabetes reducing fasting during standard oral test. most pronounced positive observed termination. also significantly increased (i.e. SaO2 level 20th min breathing O2) improved functional parameters respiratory cardiovascular systems. stimulated HIF-1α leukocytes subjects, but maximum increase was lagged. greatest changes genes occurred a coincided largest decrease levels. higher positively associated better homeostasis. In conclusion, our results suggest may be useful for preventing development type 2 diabetes. Impact statement investigated humans moderate induced expressions as well which correlated both middle-aged subjects. This small clinical trial has provided new data suggesting potential utility management patients.