The Diversity and Importance of Microbial Cytochromes P450
作者： Steven L. Kelly , Diane E. Kelly , Colin J. Jackson , Andrew G. S. Warrilow , David C. Lamb
关键词: Bacteria 、 Mycobacterium smegmatis 、 Pseudomonas putida 、 Sterol 、 Biology 、 Azole antifungal 、 Bacillus megaterium 、 Biochemistry 、 Cytochrome P450 reductase 、 Gene
摘要: The cytochromes P450 (CYPs) of microbes are enormously diverse as revealed in discoveries from the era molecular biology and subsequently found genomic investigations. One percent genes a microbe can encode CYPs, but stark contrast most bacteria studied so far survive without CYPs. Microbial eukaryotes usually have at least one CYP, due to essential requirement synthesize sterol involving CYP51, 14a-demethylase. roles vast majority microbial CYPs remain be elucidated, many already important fundamental nature, others for biotechnological purposes. Some have, course, provided facile models understanding CYP structure activity, such CYPlOl (P450(3 ĵ ) Pseudomonas putida CYP102A1 (P450gĵ _3) Bacillus megaterium. purpose this chapter is provide an outline biomedical environmental including which were unsuspected when respective microorganisms originally studied. This includes involvement some earliest metabolic alterations production penicillin, early biosynthetic steps allowing corticosteroids, first application therapeutic inhibitors, azole antifungal agents. Current future applications manifestly clear. ranging new therapeutics biotransformations bioremediation.
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