Pharmacological perturbation of murine melanoma growth by copper chelates

摘要: Abstract Groups of BDF 1 and DBA mice were treated with either the cupric chelate nitrilotriacetic acid (NTA-Cu +2 ) or cuprous neocuproine (NC-Cu +1 every other day for 7 days prior to i.p. s.c. inoculation 10 6 viable B16 melanoma cells, then 15 post-tumor inoculation. This treatment schedule was non-tosic host mice. NC-Cu acted as a tumor growth promoting factor in by enhancing tumorigenicity, stimulating body weight gain, inhibiting encapsulation tumors that permitted unrestrained ascites, increasing final over shortened survival period regardless site Treatment NTA-Cu inhibited pigmentation bearing tumors, while enhanced murine strain. These results suggest exogenous copper form chelates alters characteristics copper-requiring system both copper-chelate- murine-specific manner, further suggests activity involves nutrition concomitant alteration reactions tumors.