Actuarial disease-free survival after prostate cancer brachytherapy using interactive techniques with biplane ultrasound and fluoroscopic guidance.

摘要: Abstract Purpose: To evaluate the effectiveness and safety of interactive transperineal brachytherapy under biplane ultrasound fluoroscopic guidance in patients with localized prostate cancer. Methods Materials: Brachytherapy using 125 I or 103 Pd radioactive seeds either alone combination adjunctive external beam radiotherapy (XRT) was administered to 490 at a single institution. Post-treatment follow-up included clinical assessment disease status, assays serum prostate-specific antigen (PSA) levels documentation treatment-related symptoms complications. Results: Actuarial disease-free survival 5 yr 79% (95% CI, 71–85%), 5-yr actuarial rate local control 98% 94–99%). PSA nadir pretreatment level were found be significant predictors survival. In 1.0 ng/ml. well tolerated few post-treatment Conclusion: A broad range cancer can benefit from minimal morbidity. below 0.5 ng/ml provides useful prognostic indicator favorable long-term outcome.