Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin

摘要: 4-1BB agonist antibody treatment induces a population of KLRG1+ T cells that infiltrate melanoma tumors. We investigated the origin and function these cells, as well their place within established cell paradigms. find particularly CD4 lineage, represent novel phenotype characterized by enhanced, multipotent cytotoxicity. Distinct from described polarities, this is driven T-box transcription factor Eomesodermin. Formation requires signaling on both antigen-presenting resulting production cytokines IL-27, IL-15, IL-10. Furthermore, we CD4+ bearing signature features in livers mice infected with bacterial viral intracellular pathogens, suggesting role for infectious immunity. These constitute resolves multiple questions associated activation, including how enhances tumor-specific cytotoxicity can promote tumor immunity while repressing autoimmunity.