Preparation and Hydrolysis of 4-Amino-1H-1, 5-benzodiazepine-3-carbonitrile
作者： YOSHIHISA OKAMOTO , TAKEO UEDA
DOI: 10.1248/CPB.23.1391
关键词: Chemistry 、 Benzimidazole 、 Diazepine 、 Hydrochloric acid 、 Benzodiazepine 、 Organic chemistry 、 Tautomer 、 Hydrolysis
摘要: In the presence of hydrochloric acid, o-(2, 2-dicyanovinyl) aminoaniline is easily converted into 4-amino-1H-1, 5-benzodiazepine-3-carbonitrile, which can be hydrolyzed with various bases to other diazepine, triazepine or benzimidazole derivatives. Ethyl 5-benzodiazepine-3-carboxlate and 1, 5-benzodiazepine derivatives were also obtained from similar reactions. A remarkable tautomeric nature compound (IX) reported.
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