Interleukin 5 and phenotypically altered eosinophils in the blood of patients with the idiopathic hypereosinophilic syndrome.

摘要: We report that the hypodense eosinophil population in three patients with corticosteroid-unresponsive IHES was uniquely long lived ex vivo absence of exogenous cytokines. Serum or plasma from these conferred prolonged viability to normodense eosinophils reference donors and converted them a functionally activated phenotype. In antibody against IL-5 neutralized this activity serum, excessive quantities cytokine may account for characteristic eosinophilia long-lived, augmented phenotype disorder.