Chemokine/cytokine biology during the evolution of fibrotic disease

摘要: Although the sequence of events in pathology many interstitial fibrotic diseases is not well characterized, numerous factors that regulate immune and processes have been implicated evolution these disorders. These include potential viral infections [1], genetic variations [2], complexes [3], environmental [4] effector cell activation [5]. This last category has generated recent interest, as classification cells can no longer be limited to peripheral blood leukocytes, but must resident stromal parenchymal comprise tissue. Epithelial [6], endothelial [7], fibroblasts[8] all identified via their ability generate significant levels regulatory cytokines chemokines participate cytokine networks. Of particular interest elevated non-inflammatory express when activated. Table 1 contains representative ligands corresponding receptors for CC CXC chemokine families. list inclusive it now known there are at least four supergene families containing over 50 different proteins.