Increased sodium appetite and polydipsia induced by partial aortic occlusion in the rat.

摘要: Partly occluding the abdominal aorta between renal arteries caused rat to drink steadily increasing amounts of 2.7% NaCl when this solution and water were available. The increase in intake preceded that also occurred after aortic occlusion, intakes both fluids reaching maximal values 1-2 weeks operation. fluid drunk during day increased greatly. This change pattern drinking, together with rise drop food meant drinking was less associated feeding than it is normal rat. rats went into electrolyte deficit within 24 h partial occlusion remained for about a week (the duration balance experiment) despite water. Renal function unimpaired first 2 weeks, abnormal signs mainly rapidly reversed by removal ischaemic kidney or administration angiotensin converting enzyme inhibitor, captopril. Therefore polydipsia sodium appetite likely have been deficit, renin secretion from contributing behaviours. Arterial blood pressure rose immediately before onset drinking. Up 3 operation incidence severity hypertension did not appear depend on spontaneous changes hypertonic NaCl.