Aspirin versus the non-acetylated salicylates

摘要: Bitter im Mund, gesund Korper German proverb (Strauss, 1968) Historically, it was salicylate--as the acid, sodium salt, aldehyde alcohol or glucoside--that found application in treatment of rheumatic conditions (for review see Rainsford, 1984). These forms were present plant-derived extracts which employed from ancient times until middle last century. With development organic chemistry Germany and France at that time came first purified compounds, then later synthetic methods (chiefly Kolbe Lautermann procedure) for synthesis salicylic acid. While no clinical trials type standard today undertaken to establish efficacy acid its salts (collectively salicylates) relief pain soft tissue swelling various conditions, mere fact salicylates such wide use acceptance fever, gout other arthritides latter part century is evidence a kind their efficacy. Aspirin (acetylsalicylic acid) really only into popular through (a) recognition need obtain drug more palatable less upsetting gastrointestinal tract than salicylate, (b) powerful competitive forces operating time, (c) clever marketing approaches (Rainsford, Evidence supporting claims reduced gastric irritancy aspirin over salicylate initially based on series cleverly contrived experiments notably featuring model epithelial injury fish tails immersed acidic solutions two drugs The biological relevance this with respect mucosal must be considered remote, let alone deductive reasoning lack earlier studies basis upon especially superiority based. In contrast, decade after introduced reports ulceration dogs appeared (Chistoni Lapresa, 1909). This followed 1912 by 'gastralgia'