A Rash Analysis of National Toxicology Program Data: Predictions for 30 Compounds to be Tested in Rodent Carcinogenesis Experiments

作者: T D Jones , C E Easterly

DOI: 10.1289/EHP.96104S51017

关键词: Materials testingCarcinogenesisToxicologyRashBenzopyrenePharmacologyCarcinogenBioassayRelative potencyCarcinogenic TestingChemistry

摘要: Relative potencies for 30 compounds scheduled carcinogenic testing in the 2-year rodent bioassays were estimated based on comparisons with a wide variety of bioassay data benzo[a]pyrene, ni...

参考文章(16)
BETTE HILEMAN, Expert intuition tops in test of carcinogenicity prediction Chemical & Engineering News. ,vol. 71, pp. 35- 37 ,(1993) , 10.1021/CEN-V071N025.P035
L S Gold, T H Slone, L Bernstein, Summary of carcinogenic potency and positivity for 492 rodent carcinogens in the carcinogenic potency database. Environmental Health Perspectives. ,vol. 79, pp. 259- 272 ,(1989) , 10.1289/EHP.8979259
Lois Swirsky Gold, Charles B. Sawyer, Renae Magaw, Georganne M. Backman, Margarita De Veciana, Robert Levinson, N. Kim Hooper, William R. Havender, Leslie Bernstein, Richard Peto, Malcolm C. Pike, Bruce N. Ames, A carcinogenic potency database of the standardized results of animal bioassays Environmental Health Perspectives. ,vol. 58, pp. 9- 319 ,(1984) , 10.1289/EHP.84589
Raymond W. Tennant, Judson Spalding, Stanley Stasiewicz, John Ashby, Prediction of the outcome of rodent carcinogenicity bioassays currently being conducted on 44 chemicals by the National Toxicology Program Mutagenesis. ,vol. 5, pp. 3- 14 ,(1990) , 10.1093/MUTAGE/5.1.3
Troyce D. Jones, Phil J. Walsh, Elaine A. Zeighami, Permissible Concentrations of Chemicals in Air and Water Derived From Rtecs Entries: a "Rash" Chemical Scoring System: Toxicology and Industrial Health. ,vol. 1, pp. 213- 234 ,(1985) , 10.1177/074823378500100414
Bruce A. Owen, Troyce D. Jones, Hazard evaluation for complex mixtures: relative comparisons to improve regulatory consistency. Regulatory Toxicology and Pharmacology. ,vol. 11, pp. 132- 148 ,(1990) , 10.1016/0273-2300(90)90017-6
T.D. Jones, G.D. Griffin, P.J. Walsh, A unifying concept for carcinogenic risk assessments Journal of Theoretical Biology. ,vol. 105, pp. 35- 61 ,(1983) , 10.1016/0022-5193(83)90423-X
Troyce D. Jones, Phillip J. Walsh, Annette P. Watson, Bruce A. Owen, Larry W. Barnthouse, Dee A. Sanders, Chemical scoring by a rapid screening of hazard (RASH) method. Risk Analysis. ,vol. 8, pp. 99- 118 ,(1988) , 10.1111/J.1539-6924.1988.TB01157.X