Toxicological potency of 2,3,7,8-tetrachlorodibenzo-p-dioxin relative to 100 other compounds: a relative potency analysis of in vitro and in vivo test data.

摘要: A common definition of relative potency is the dose a reference compound required to cause particular incidence specific toxic response divided by test needed an equal that same effect. In this simple manner, toxicological assessments for chemical concern can be made in terms another about which much known from human health perspective. Relative factors were used compare 2,3,7,8-tetrachlorodibenzo-p-dioxin CAS # 1746-01-6 (TCDD) with 100 other compounds both individually and collectively. All results standardized scale spanned many orders magnitude was indexed arbitrary unity benzo(a)pyrene [B(a)P]. From comparisons between 2,771 pairs bioassay (i.e., matched experimental design conditions) TCDD compared compounds, it found 600 times as B(a)P (interquartile range 130 1,900). The distribution values fitted accurately log-normal function having untransformed mean 550 slope inverse standard deviation distribution) 140. These combined (a) lifetime carcinogenic risk level 1/100,000 (b) universal, potency-dependent coefficient (estimated collection epidemiologically-based carcinogens) yielded estimates equally concentrations should 13 pg/m3 7 pg/L air water, respectively.