Induction of DNA strand breakage and apoptosis in the eel Anguilla anguilla.

摘要: The ability of benzo[a]pyrene, Aroclor 1254, 2-3-7-8-tetrachlorodibenzo-p-dioxin and β-naphthoflavone to induce DNA strand breaks (SB) apoptosis in erythrocytes the European eel (Anguilla anguilla) was investigated following by vivo exposure. damage evaluated Comet assay, while diffusion assay used investigate induction 7 days after a single intraperitoneal administration. 2-3-7-8-Tetrachlorodibenzo-p-dioxin induced highest genotoxic effect, followed other two substances had limited effects. A significant observed at doses exposure when also elevated. occurrence apoptotic cells Aroclor, quite variable did not show clear dose-related responses. role oxidative stress mediating discussed.