Use of short term test systems for the prediction of the hazard represented by potential chemical carcinogens

摘要: It has been hypothesized that results from short-term bioassays will ultimately provide information be useful for human health hazard assessment. Historically, the validity of tests assessed using framework epidemiologic/medical screens. In this context, carcinogen (long-term) bioassay is generally used as standard. However, approach widely recognized being biased and, because it employs qualitative data, cannot to assist in isolating those compounds which may represent a more significant toxicologic than others. contrast, goal research address problem evaluating utility assessment an alternative method investigation. Chemicals were selected mostly list carcinogens published by International Agency Research on Carcinogens (IARC); few other chemicals commonly hazardous included. Tumorigenicity and mutagenicity data 52 obtained Registry Toxic Effects Chemical Substances (RTECS) analyzed relative potency approach. The evaluated format allowed comparison ranking mutagenic potencies (as estimated more » data) vs. tumorigenic chronic bioassays). Although was preliminary investigation, offers evidence systems hazards represented contribute increased carcinogenesis humans result occupational or environmental exposures. 177 refs., 8 tabs. « less